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Organoid research is revolutionizing our understanding of human biology by providing three-dimensional, physiologically relevant models of human tissues. Key techniques include patch clamp electrophysiology, microelectrode arrays (MEAs), and optical manipulation, each of which unique advantages for studying the functional properties of organoids.

A recent Eli Lilly study highlights Jacketed External Telemetry (JET) as the superior method for nonclinical QTc assessment, outperforming multilead snapshot recordings in both statistical and pharmacological sensitivity. JET’s ability to capture high-fidelity ECG data from conscious, freely moving animals makes it more clinically relevant and regulatory-aligned. Backed by 2022 ICH E14/S7B updates, JET sets a new standard for cardiac safety in toxicology studies.

Our free guide compiles a range of experimental protocols to help guide researchers through the processes of culturing and seeding different types of organoids.

Researchers at McGill University in Montreal, Quebec investigated the role of Doublecortin (DCX) in regulating neuronal branching through its influence on tubulin polyglutamylation. 

In a move that could reshape the landscape of preclinical drug development, the Food and Drug Administration (FDA) recently announced a plan to phase out its requirement for use of animal models in evaluating monoclonal antibodies (mAbs) and other drug candidates.

Facing funding challenges? This blog from Harvard Bioscience explores diverse alternative funding sources for researchers—from private foundations and industry partnerships to international grants and crowdfunding. It also highlights key awards supporting early-career scientists. Discover practical paths to keep your research moving forward, even in uncertain times.

The SoHo Telemetry System revolutionizes small animal model research by enabling real-time physiological monitoring alongside behavioral analysis without disrupting natural movement. With wireless efficiency, extended transmission distance, and seamless integration, SoHo enhances studies in stress, neuroscience, sleep, motor disorders, cognition, and metabolism. Researchers gain greater accuracy, efficiency, and reproducibility, making SoHo a game-changer in preclinical research.

Retinitis pigmentosa (RP) and retinal dystrophy are debilitating genetic disorders that lead to progressive vision loss due to the degeneration of photoreceptor cells in the retina. Despite advances in genetic research, effective treatments remain limited, making the development of innovative research models crucial. Organoids and Mesh MEA (microelectrode array, also referred to as multielectrode array) technology from Multi Channel Systems have emerged as powerful tools in studying these diseases, providing insights into retinal function and potential therapeutic approaches.

A recent study from Great Ormond Street Hospital suggests that commonly prescribed nitrogen scavengers for Urea Cycle Disorders (UCD) may contribute to Branch Chain Amino Acid (BCAA) depletion, highlighting the need for a balanced approach that optimizes protein intake and considers alternative treatments.

DSI's SoHo Implantable Telemetry platform revolutionizes small animal research by enabling comprehensive biopotential monitoring. Capture EEG, EMG, ECG, body temperature, and locomotor activity with minimal invasiveness. Designed for extra-small to medium animal models, this system enhances research precision, reduces experimental stress, and provides unprecedented insights across neuroscience, cardiovascular, and behavioral studies.

Organoid electrophysiology is providing pharmaceutical and biotech companies with human-relevant models for testing drug efficacy, modeling diseases, and reducing reliance on animal studies, ultimately accelerating the development of safer and more effective therapeutics.

Wildfire smoke poses a growing public health threat, with harmful pollutants like PM2.5 linked to respiratory and cardiovascular issues. This blog explores the health impacts of wildfire smoke, highlights recent research advancements, and showcases innovative tools like DSI’s inhalation exposure systems and telemetry solutions. Discover how these technologies are helping researchers uncover the mechanisms behind smoke-related health risks and develop interventions to protect vulnerable populations.

The integration of behavioral telemetry and organoid research is transforming neuroscience and biomedical science by linking cellular models with complex biological behaviors.

Revolutionize your diabetes research with DSI’s continuous glucose telemetry system. This innovative technology enables real-time, long-term glucose monitoring in animal models, offering stress-free, comprehensive data collection. By bridging preclinical and clinical research, it supports breakthroughs in glycemic control and translational therapies. Learn how it’s shaping the future of diabetes treatments.

Organoid technology is poised to revolutionize the development of brain-controlled prosthetics. By bridging the gap between the body’s central nervous system and a synthetic device, research with neural organoids could lead to the development of prosthetics capable of real-time interaction with the human brain through closed-loop feedback systems. Multielectrode array technology (also called “microelectrode array” or “MEA”) from Multi Channel Systems is ideally suited for studying this complex interaction and developing innovations in prosthetic research.

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PTSD affects millions, with varied trauma responses complicating treatment. Advanced research tools, including telemetry and behavioral systems, help uncover physiological and behavioral insights, paving the way for personalized therapies. Studies highlight sex-specific stress adaptations, novel drug targets, and physiological biomarkers, advancing understanding and treatment options for this complex disorder. Continued innovation is key to improving PTSD care.

Unlike traditional MEA recordings that can only measure field potentials, the IntraCell uses a laser to precisely optoporate cardiomyocytes underneath each electrode. 

Lung fibrosis is a serious condition that limits lung function, and traditional research methods often rely on invasive techniques. However, Whole Body Plethysmography (WBP) offers a noninvasive solution for tracking fibrosis progression over time. This method allows researchers to monitor lung function in animal models without terminal procedures, providing valuable insights for developing effective treatments and understanding disease development.

Unlock the future of Alzheimer’s research with groundbreaking lab tools from Harvard Bioscience. This video showcases how our cutting-edge technologies, including BTX's electroporation systems, Biochrom's molecular analysis tools, and advanced electrophysiology solutions, accelerate discoveries in Alzheimer’s disease. From gene therapy to live cell imaging and cognitive testing in animal models, watch how Harvard Bioscience is building labs to advance Alzheimer’s research and equip the next generation of scientists with tools that could lead to life-changing breakthroughs.

According to a recent study published by The Lancet Neurology with contributions from the World Health Organization (WHO), neurological conditions such as, dementia, epilepsy, stroke, and migraine affect more than three billion people worldwide, making these conditions the leading cause of illness and disability globally. Despite advances in neuroscience research, many of these conditions do not have fully effective treatments, making the development of innovative therapies a pressing need.

Microelectrode arrays – also known as “multielectrode arrays” or MEAs – are powerful tools used in neuroscience, cardiac research, and pharmacology to study the electrical activity of excitable tissues like neurons and cardiac cells. But what exactly is an MEA system, and how do they work?